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Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)-relationship to newly identified mitochondrial pyruvate carrier proteins

Comprehensive Cellular Protection Beyond just cleaning up, glutathione acts as a shield for the most sensitive parts of the cell: DNA Protection: It prevents oxidative damage to DNA, reducing the risk of mutations

The pattern is unmistakable: the evidence is deepest where it matters least for a clinical claim (cell dishes, gene assays, patents) and thinnest exactly where it would matter most (controlled human trials with counted hair as the endpoint)

Furthermore, high IGFBP5 expression correlated with shorter survival after CTLA-4 blockade in a melanoma cohort, suggesting that IGF-axis activation may contribute to ICB resistance across tumor types